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SIRT2 interacts with the GTPase domain of septin4 and deacetylates K174 on septin4, suppressing the cleaved caspase-3 and cleaved-PARP1 pathway, further alleviating Ang II-induced hypertensive kidney injury and glomerulosclerosis

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Interestingly, the SOD activity in the red blood cells was elevated in ASD children if compared to the control group and that is probably because this mechanism acts against the cell damage caused by the oxidative stress in the brain (Pangrazzi et al., 2020a)