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used asiatic acid to treat RA-FLSs and reported that increasing concentrations of asiatic acid significantly increased the expression of the Nrf2/HO-1 protein and inhibited downstream NF-B signalling, which in turn increased the expression of proapoptotic proteins (Bax and caspase-3) and decreased the expression level of the antiapoptotic protein Bcl-2, increasing the level of apoptosis and inhibiting the proliferation and cloning of RA-FLSs

421 However, neutrophils from p110-deficient mice efficiently migrated to N-formyl-Met-Leu-Phe (fMLP) with normal rates and directions, 447 implying that the generation of PIP3 is not required for fMLP-directed chemotaxis

Single-cell transcriptomic analysis reveals that FADS-induced changes occur both in the tumor cells and the intra-tumoral CD8 + T cells

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This observation suggests a potentially different mechanism underlying the suppressive effects of LDH inhibition in NB, it may extend beyond its recognized metabolic functions in tumorigenesis