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The systemic inhibition of GSH synthesis by L-buthionine-S-R-sulfoximine (BSO, In the cerebellum, EAAT3 up-regulation and increased GSH levels were associated with an earlier activation of the NGF/TrkA and mTOR signaling pathways in neurons ( Nerve growth factor is a neurotrophin (NT) that regulates neuronal development, differentiation, plasticity, cell death and survival ( In the human and murine CNS, NGF- and TrkA-positive regions correlate with the anatomical distribution of cholinergic neurons in the basal forebrain and striatum (Yamamoto et al., 1996)

The intramuscular route avoids digestive absorption issues without requiring a full IV infusion visit

doi: 10.2337/dc10-0132

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Week five through six: Move to daily application if every-other-day causes no issues