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23 Once these cells migrate into peripheral blood, they transition into a quiescent state, reduce their proliferative activity, downregulate CD5, and restore CXCR4 expression, 24 resulting in the CD5 low CXCR4 high subset, known as long-term circulating cells (LTCs)

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The results of comparing healthy controls and patients with A pathology alone with A together with tau pathology indicate that A is associated with disturbances in iron balance, as evidenced by lower NCOA4 expression, and a decrease in GPX4 antioxidant enzyme expression in the grey matter