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Whole blood and plasma samples of six JVC rats were collected at 0.05, 0.167, 0.5, 1, 2, 4, 8, 24, 48, and 72 h after administration (three males and three females at each time point) for the examination of radio pharmacokinetics of total plasma

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Describe the primary pathways through which estrogen metabolites are excreted from the body, emphasizing the role of the organs involved in the elimination process