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Collectively, our findings demonstrate that the GPX4 inhibition by RSL3 in PTC cells induces cell death, ferroptosis, lipid peroxidation, increased intracellular ROS burden, and significantly impairs thyroid tumor cell migration, 3D PTC spheroid fotmation and results in reduced spheroid viability in vitro

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Additionally, the presence of potassium channel blockers attenuates the vasodilatory effects of U

Uzunova V, Sheline Y, Davis JM, Rasmusson A, Uzunov DP, Costa E, et al

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Transgenic Res 18:787799