benefits of combining cd38 inhibitor with 5-amino-1mq blocks an enzyme called NNMT, and the mechanism is real, but NNMT overexpression does not track body fat. It tracks insulin resistance. Non-diabetic individuals at BMI 33 had normal NNMT. And Exploring NNMT: from metabolic pathways

Exploring NNMT: from metabolic pathways to therapeutic targets Archives of Pharmacal Research Springer Nature Link Immunomodulatory properties of CD38 antibodies and their effect on anticancer efficacy in multiple myeloma Bisht 2023 Cancer Medicine Wiley Online Library A Potent and Specific CD38 Inhibitor Ameliorates Age Related Metabolic Dysfunction by Reversing Tissue NAD+ Decline ScienceDirect NAD for Aging: How It Supports Longevity and Cellular Health Goldman Anti CD38 antibody therapy for patients with relapsed refractory multiple myeloma: differential mechanisms of action and recent clinical trial outcomes Annals of Hematology Springer Nature Link Biological Functions and Therapeutic Potential of NAD+ Metabolism in Gynecological Cancers

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