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Considerations should include frailty assessment, polypharmacy management, individualized immunosuppression, and age-specific applications of novel targeted therapies

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Despite the given role of sensory responsiveness in sleep reduction, it is noteworthy that lateral line ablation did not have an impact on sleep in four separate populations of cavefish (Jaggard et al

128,129 Conversely, USP4, USP10, and USP18 mitigate metabolic dysfunction by reducing hepatic steatosis, hyperglycemia, and inflammation, suggesting therapeutic potential against MASLD and T2DM

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