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To further clarify the most relevant metabolic pathways in GDM and HP, pathway analysis showed the detailed impacts of GDM/HP-related alterations in metabolic networks

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A study found that the NRF2-KEAP1 complex keeps shuttling constantly between the cytoplasm and the nucleus, and in the nucleus, the nuclear protein prothymosin competes for NRF2 binding to KEAP1 and enables the liberated NRF2 to activate NRF2 target genes [15]