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Mitochondrial ferritin (FtMt), a mitochondria-localized iron storage protein with iron-binding affinity comparable to cytosolic ferritin [80], contributes to the maintenance of mitochondrial iron homeostasis [81]

Cataracts prevalence is raised exponentially with age, affecting 3.9% of individuals aged between 55 and 64 years and rising to reach 92.6% in patients aged 80 years or more [6,7,8]

On the other hand, since the cBAF complex and the PBAF complex contain SMARCA4 and SMARCA2 mutually exclusively, the absence of SMARCA4 does not affect the function of the cBAF subcomplex and the PBAF complex, including SMARCA2

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Notably, PD patient substantia nigra samples reveal approximately 80% reduction in CP activity, correlating with aggravated iron deposition and DA neuron death

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