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BDNF has been shown to modulate mTORC1 signaling specifically in the neurons to promote synaptic plasticity and neuronal growth 37,38

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4: Heat denaturation of proteins Aqueous solutions of the proteins (RuBisCO and alkaline phosphatase) and peptide (glutathione) were denatured by heat treatment, which has been used in many previous studies as summarized in Supplementary Table 3