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Skin improvements from addressing B12 deficiency typically become noticeable within 4-8 weeks of consistent adequate intake

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It significantly upregulates VEGF (vascular endothelial growth factor) expression, stimulating endothelial cell proliferation and tubule formation

Vitamin B12, found in foods like meat and dairy, is essential for energy

In particular, mitochondrial DNA is vulnerable to oxidative stress because it is located in the mitochondrial inner membrane, where a substantial amount of ROS is produced.106 Mitochondrial injury and oxidative stress form a vicious cycle