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These patients suffer as a result of diagnostic delay, fear of sudden onset of an attack, adverse reactions to treatment, and a lack of psychological support.13 The incidence of anxiety and depression among patients with TN is nearly 3 times higher than in the general population,14 as a result of the intensity of pain and long duration of the disease

Each route has distinct bioavailability and absorption rates, directly influencing the effective dosage

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This means they easily penetrate the BBB (Blood-Brain Barrier) and the CNS (Central Nervous System) , which are composed primarily of fatty tissue