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Abou-Zeina, H

1 Despite the availability of multiple treatments, a substantial proportion of patients either fail to achieve remission, particularly in cases of treatment-resistant depression (TRD) and late-life depression

doi: 10.1371/journal.pone.0196921 90 YangMChenXHuXLiHHuangHFangYet al

Simultaneously, insulin resistance, both at the hepatic and systemic level, exacerbates lipid accumulation and impairs glucose homeostasis, compounding the metabolic burden