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Methods Enzymol 401:18 Margis R, Dunand C, Teixeira FK, Margis-Pinheiro M (2008) Glutathione peroxidase family - an evolutionary overview

PMID: 33044755 InflammationInhibition of Fibroblast Growth Factor Receptor by AZD4547 Protects Against Inflammation in Septic Mice

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For instance, activation of NRF2 promotes ROS clearance in drug-resistant liver cancer cell lines [31]

Mechanistically, GLPs exert renoprotective effects by suppressing the PI3K/Akt/mTOR signaling cascade, promoting autophagicevidenced by increased Beclin-1 expression and LC3-II/LC3-I ratio, along with decreased p62 accumulationwhile simultaneously attenuating apoptotic activity (reducing caspase-3 and caspase-9 levels) and dampening pro-inflammatory responses (lowering IL-6, IL-1, and TNF-)

doi: 10.1016/j.drudis.2008.11.006 14 BrancatoVOliveiraJMCorreloVMReisRLKunduSC