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Iron depletion by deferoxamine up-regulates glucose uptake and insulin signaling in hepatoma cells and in rat liver

Mechanistically, erucic acid orchestrates this inhibition by impeding STAT3 phosphorylation and promoting ferroptosis

Science 366 , 818822 (2019)

The estrogen receptor enhances AP-1 activity by two distinct mechanisms with different requirements for receptor transactivation functions

These activities occur both through direct protein-disulfide reductions and via the transfer of this reducing power to Trx-dependent peroxiredoxins and methionine sulfoxide reductases [48, 49], or to GSH-dependent glutathione peroxidases [43]

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