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Puesto que la simple exploracin clnica puede no ser suficiente para conseguir un diagnstico preciso, las manchas melnicas que aparece en un perodo corto deberan ser extirpadas para establecer su verdadero diagnstico y excluir la posibilidad de melanoma.

Clinically, oral melanoma may present as an asymptomatic, slow-growing brown or black patch with asymmetric and irregular borders or as a rapidly enlarging mass associated with ulceration, bleeding, pain and bone destruction