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The Jak-STAT pathway stimulated by interferon gamma

Furthermore, using redox-sensitive GFP2 (roGFP2) 9,34,35 as a tool for functional analysis of glutaredoxins, we determined that the inactive monothiol glutaredoxin AtGrxS15 from Arabidopsis thaliana 36 is able to utilize glutathione disulfide (GSSG) but not GSH as a substrate

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In contrast, the detrimental effect of mitophagy mostly occurs in scenarios of excessive activation or abnormal regulation: when cells encounter sustained and severe pathological stress (such as severe ischemia and severe inflammation), mitophagy is abnormally activated, which excessively degrades functionally normal mitochondria, leading to disorders of cellular energy metabolism, insufficient ATP synthesis, and simultaneous disruption of the normal proliferation and renewal balance of mitochondria in cells

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