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[4] The results of various studies have shown the potential of Vitamin B12 in treating post-herpetic neuralgia and painful peripheral neuropathy due to its role in nerve repair

11 Cancer Research Cancer cells exhibit a unique metabolic phenotype known as the Warburg effect, characterized by increased glycolysis even in the presence of oxygen, which is supported by elevated NAD+ levels

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Everyone else reports anywhere from a few weeks to 3 months relief

This also results in the reduced production of intrinsic factor which can then interfere with vitamin B12 absorption

The 1 mg dose has direct human diabetes-trial activity. Below 1 mg is more speculative