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Beyond its proteolytic function, PR3 serves as the major autoantigen in anti-neutrophil cytoplasmic antibody-associated vasculitis, conferring special relevance in autoimmune diseases ( CatG exhibits distinctive dual biological characteristics, effectively degrading various extracellular matrix proteins while possessing significant antimicrobial activity

doi: 10.1164/rccm.201110-1767OC

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Wang et al., 2010)

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By contrast, no significant changes in 4HNE levels were observed across groups, indicating selective modulation of oxidative stress markers [2]