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Lysosomal dysfunction, whether through altered pH, reduced enzymatic activity, or defective membrane transport, further limits payload activation and effective drug release

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[11] This concept of biased agonism may eventually explain ipamorelin's selectivity profile and guide the design of even more selective GH secretagogues

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82273552, 82203947, 82073445), the Natural Science Foundation of Jiangsu Province (BK20210049), CAMS Innovation Fund for Medical Sciences (CIFMS-2021-I2M-1-001), and the Fundamental Research Funds for the Central Universities (Grant No

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