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The pharmacophore of GSH was evaluated by Molinspiration and SwissADME

SR4 is a small-molecule mitochondrial uncoupler previously identified by our research group for its potent anticancer activity in vitro and in tumor xenograft models (12-14)

Lancet 364 (9447), 17891799

The main constraint of curcumin lies in its limited bioavailability, with only a minimal fraction of the substance reaching the bloodstream in a biologically active form