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3 Ferroptosis: a novel player in depression pathogenesis Dixon and his team introduced the concept of ferroptosis in 2012, characterizing it as an iron-dependent mode of programmed cell death marked by the build-up of lipid hydroperoxides (Dixon et al., 2012)

As a method of ruling in hyperthyroidism, a cTSH sample is non-specific, but the addition of a TT 4 (or FT 4 ) can increase diagnostic accuracy to near 100% (Peterson et al, 2015)

Metabolomics is also involved in assessing treatment response

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Additionally, a recent study (198) suggests that R-SH, an OSM, could serve as a biomarker for IBD, proving more sensitive than C-reactive protein (CRP) in detecting moderate endoscopic activity, though less sensitive than fecal calprotectin, with age and albumin levels as potential confounding factors, and indicates that R-SH may improve IBD monitoring

Studies have shown that GSDM mediated pyroptosis plays an important role in pathological processes such as neuroinflammation and mental diseases