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In fact, the study conducted by Romero et al

622,623 DNA methylation may also affect the expression of tumor-associated antigens, leading to immune evasion

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however, current methodologies lack the precision required to achieve spatiotemporal control over cellular differentiation pathways, raising concerns about tumorigenic risks or aberrant tissue remodeling

Murine models were inoculated with murine B16 melanoma (B16M) to obtain in vivo metastatic melanoma that was subsequently tested with the above-stated combination treatments

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