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NAE reports associated with GLP-1 RAs were extracted, and disproportionality analysis was performed to identify NAEs significantly disproportionately related to these agents, which were defined as GLP-1 RA-related NAEs in this work

Minimal risk of systemic side effects

PMID 24287781

Animal Model:180-200 g, Female Wistar rats [3] Dosage:10 g/kg Administration:I.p

So I asked again

As expected, no band corresponding to the molecular size of Ea-domain (~4 kDa) was detected in the lysate of HEK293 cells overexpressing IGF-1Ea or tissues confirming that the E-domain was not cleaved intracellularly from the IGF-1 mature protein