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Probiotic fermentation technology (PFT) has been reported to improve insulin signalling by modulating the gut microbiota, upregulating insulin receptor expression and activating PI3K/Akt signalling, followed by inhibition of GSK-3 and mTOR signalling, which leads to the downregulation of over-phosphorylated tau proteins in order to halt the development of memory and cognitive impairment (129)

1994]Regulation of ovine fetal pituitary function by corticotrophin-releasing hormone, arginine vasopressin and cortisol in vitro

Subsequent investigations have demonstrated that histone Kla can directly enhance the transcription and expression of stable genes by modulating chromatin accessibility

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