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TalleyNJVerlindenMGeenenDJHoganRBRiffDMcCallumRWet al

Dabigatran is a P-gp substrate but is not metabolized by CYP3A4, so the pharmacokinetic concern would be limited to P-gp

Of note, there is always a higher conversion rate of SAMe into SAH during such protracted L-methionine treatment [126]

10.1042/cs0820471 348

However, despite this radically different composition, the cellular uptake by HeLa cells was not substantially different among the particles separated using the two techniques, perhaps due to the dissociation of soft corona after dilution of NPs before the treatment