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Our analysis showed no significant differences in the expression of mitochondrial genes or related pathways between wild-type and hepsin / mice at any time point, as determined by transcriptome analysis, pathway enrichment, and GSEA

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designed a US-triggered MnWO X nanosystem modified with PEG (termed MnWO X -PEG) to endow the capability of GSH-enhanced ROS ( 1 O 2 and OH) production for killing malignant tumors (Figure 6D) ( X -PEG exhibited significantly time-dependent GSH consumption capacity through reducing W 6+ to W 5+ (Figure 6E), cooperating with increased ROS to achieve a powerful inhibition effect on tumors (Figure 6F)

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