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In many cases, B12 shots are available by prescription only

Malabsorption Issues- Certain medical conditions, such as pernicious anaemia or gastrointestinal disorders, can interfere with the bodys ability to absorb B12 from food

[8] [9] HCG should not be used by women who are pregnant or planning to become pregnant during treatment

They are given as intramuscular injections, usually in the upper arm

If you intend to supplement vitamin B12, choose a form with methylcobalamin, hydroxocobalamin, adenosylcobalamin, or a combination of these (avoid cyanocobalamin, if possible)

So, the route of administration matters