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In contrast, high xCT expressing cell lines derived from breast, kidney, ovarian, and colorectal cancers did not exhibit increased dependence on GLUT1, suggesting that high xCT expressing cells from these tumor types would not synergistically respond to combined GCL and GLUT1 inhibition

Cancer Res 66(18):92359244 Tang J, Karbhari N, Campian JLJC (2025) Therapeutic targets in glioblastoma: Molecular pathways, emerging strategies, and future directions