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Although these antibodies were selected on the basis of cytolysis, it is possible that some of their therapeutic effects may be mediated by inhibition of the NADase activity and subsequent NAD boosting effects

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The protective role of upregulated GPx3, manifested by the suppression of the growth of melanoma cells via the ROS mechanism, has been attributed to the inhibition of HIF1, an important factor frequently elevated in various malignancies (Yi et al

Once the nanoparticles were internalized by cancer cells, the ferric ions released from the bone structure of the MOFs could be reduced by metal reductase or GSH and then triggered the Fenton reaction to produce ROS, and high ROS concentrations caused severe lipid peroxidation

After 6 h of treatment with CuCl 2 , no significant dose-dependent changes or differences between cell types were detected (Fig