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Biologically, humans produce a specific transport protein for ergothioneine (OCTN1), rendering it highly bioavailable and readily retained

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If wheat was eaten before most or all episodes, and even if tolerated at other times, skin testing to gluten flour (which is enriched in wheat protein compared to regular flour) and/or specific IgE testing to wheat and Tri a 19 should be considered given the possibility of cofactor-dependent wheat allergy, which can masquerade as IA [31, 32]

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One of the reasons this is taking place is that the US is in the middle of an obesity health crisis with the prevalence of obesity among U.S