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A member of the RAS superfamily, ADP ribosylation factor 6 (ARF6), acts as a downstream of the KRAS/extracellular signal-regulated kinase (ERK) pathway to increase the proliferation and Warburg effect of pancreatic cancer cells

Despite there is no consensus on regarding the features a binding site must have to be druggable, some authors may argue that features like hydrophobicity, shape, size, or even the combination of them are pivotal to make a site druggable 101,102,103

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TABLE 1 Key amino acids of FXN identified as impaired variants

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