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In one study, total ceftriaxone concentrations (bound and unbound) were measured in middle ear fluid obtained during the insertion of tympanostomy tubes in 42 pediatric patients with otitis media

These polymorphisms have been linked to busulfan PK and clearance in particular, with patients who have high GST-metabolizing capacity being at risk of developing VOD through rapid depletion of intracellular glutathione GSH (105)