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2019;7:e7023

198 However, the efficacy of antioxidants in clinical trials for AD remains uncertain

Our study revealed negative regulation of LRP1-binding proteins (e.g., TIMP2, FN1, SERPINE2, MMP2, DCN, C1S, C1R, and CTSD) in chondrocytes exposed to H 2 O 2 , corroborating findings from LRP1 knockdown models [85], except for PSAP, which was downregulated in our study but upregulated in LRP1 knockdown models