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( a ) Cells with shTMLHE were incubated with 13 C 2 -acetylcarnitine, and M + 2 acetyl-CoA was assessed (n = 8 technical replicates representative from 2 independent experiments)

As a promising adjunctive or standalone strategy, FMT offers a feasible and innovative approach to microbiota-targeted therapy in the management of CRC

However, like other TKIs, lenvatinib often causes adverse drug reactions such as hypertension, diarrhea, proteinuria, and fatigue, which may lead to dose interruption or discontinuation (Kudo et al., 2018), (Kim et al., 2021)

ludwiggi protects against DSS-induced colitis by enhancing the choline/7nAChR-mediated dendritic cell immune tolerance, leading to increased Foxp3 + Treg differentiation ( + dendritic cells from Enterobacter ludwiggi -treated mice exhibited higher expression of tolerogenic markers Tgfb1, Tgfb2, Aldh1a2 , and Pdl1 , and co-culture with nave CD4 + T cells enhances Treg conversion ( Enterobacter ludwiggi exhibited reduced colitis severity and expanded Treg populations in the mesenteric lymph nodes and spleen, highlighting cholines role in shaping gut-immune interactions

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