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Description

LDH is highly conserved, and the lack of isoform selectivity leads to notable on-target toxicity

when degeneration in these neurons reaches a threshold reduction of 80% dopamine, the motor symptoms of PD emerge 29

Cynomolgus monkeys were selected to explore the therapeutic potential of our molecule

Immunity 53 , 12961314.e9 (2020)

Thus, we reason that the extended hyper-inflammation in Mac-CF lungs must be due to prolonged intracellular stimulation and/or hyper-responsiveness of Mac-CF macrophages