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The MD was initially recognized for cardiovascular protection, but it has also been shown to boost cognitive health and reduce the risk of AD

When vitamin B12 levels are low, myelin production can suffer, leading to communication breakdowns in the nervous system

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This suggests that CD38 might be a potential additional immunotherapeutic target in HCC and NSCLC, and can be used together with PD-1/PD-L1 immunotherapy ( Reasons for Choosing CD38 as a Therapeutic Target The main reasons why CD38 has become a tumor treatment target are as follows: (1) In a hypoxic TME, CD38 acts as an extracellular enzyme to catalyze NAD + existing in the TME into ADPR or cADPR

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