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In mouse studies, it approximately doubled the population of BrdU-positive cells (a marker of new cell growth), enhanced synaptogenesis markers at both mRNA and protein levels, and rapidly increased BDNF expression in the hippocampus

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17 Effect of the HGF mimetic, Dihexa, on c-Met activation

& Arias, J

Clinical trials demonstrated average weight reductions of 15-21% of body weight over 72 weeks in people with obesity (SURMOUNT-1), while more modest weight loss was observed in type 2 diabetes patients (SURPASS trials)