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We hypothesized that given the centrality of glutathione to protect from ferroptosis, depletion of its precursors, cysteine and methionine, should sensitize cells to undergo ferroptosis

[DOI] [PubMed] [Google Scholar] 56.Zastre J.A., Sweet R.L., Hanberry B.S., Ye S

GSH produced a rapid and significant decrease in both systolic and diastolic blood pressure, within ten minutes, but which returned to baseline within 30 minutes, in both groups of hypertensive patients and in non-hypertensive diabetics, but had no effect in normal healthy subjects

Antimycobacterial activity

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In adult quiescent stem cells, which are highly FAO-dependent, -KG levels and the -KG/succinate ratio are expected to be low, potentially restraining demethylase activity and locking cells in a more methylated, quiescent chromatin state