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Excess MPO appears to play a role in atherosclerosis by accumulating in the lining of arteries, where it promotes oxidative stress and inflammation, impairs nitric oxide, and contributes to endothelial dysfunction

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When the membrane potential is below, at, or near rest, a magnesium ion blocks the open NMDA receptor and prevents other ions from moving through the channel

Notably, UDE application, containing 100 M -EC, significantly reduced NO generation compared to the control (Fig

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