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It is important to note that the enteric microbiome and its metabolic products are not static and can be altered throughout the life cycle of the individual, with the first 18 months of life being an especially important time for the development of a stable enteric microbial ecosystem (150)

One of the fundamental principles of therapeutic drug development is confirmation of end-target engagement, measured most readily and ideally via serum biomarkers

& Jankovic, J

[DOI] [PubMed] [Google Scholar] 42.Wang HH, Portincasa P, de Bari O, Liu KJ, Garruti G, Neuschwander-Tetri BA, Wang DQ

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