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Discussion Significance of the study To our knowledge, this is the most comprehensive network meta-analysis comparing the efficacy of SL, IM, and oral routes of administration of vitamin B12 in patients with vitamin B12 deficiency

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Published research documents their roles in extracellular matrix regulation, fibroblast activity, and growth factor expression

This clean safety profile contributed to the FDA granting GRAS (Generally Recognized As Safe) status for AOD-9604 as a food ingredient in 2007