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Botulinum Toxin Treatment of Pain Disorders

In parallel, surface expression of the M1-like marker CD80 was determined (see gating strategies for intracellular and surface staining analysis in left-side plots)

Appl Microbiol Biotechnol 107 , 44714492 (2023)

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CYP2D6 Metabolism and Pharmacogenomic Variability The liver converts hydrocodone to hydromorphone via CYP2D6 O-demethylation, producing an active metabolite with approximately 30 times higher mu-opioid receptor affinity than the parent compound