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Activation of I 1 receptors in these regions facilitates endogenous sympatholytic signaling, synergizing with the central 2 pathway to reduce blood pressure and peripheral resistance (Szabo, 2022)

Among the proteins with increased expression in ME/CFS were 3-hydroxybutyrate dehydrogenase type 1 (BDH1) and acetyl-CoA acetyltransferase 2 (ACAT2), both of which are integral to fatty acid metabolism and processing of ketone bodies