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[4] Function [edit] Aspartate transaminase catalyzes the interconversion of the natural amino acid, L-aspartic acid and -ketoglutaric acid to give oxaloacetic acid and L-glutamic acid.: As a prototypical transaminase, AST relies on PLP (vitamin B 6 ) as a cofactor to transfer the amino group from aspartate or glutamate to the corresponding ketoacid

doi: 10.1016/S0140-6736(04)16305-8 126 WiseRMWagenerAFietzekUMKlopstockTMosharovEVZuccaFAet al

However, from basic mechanistic studies to translational applications, numerous critical challenges and unresolved questions remain