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Indication: As an adjunct treatment to minimize the occurrence of toxicity associated with cisplatin chemotherapy

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Unfortunately, drug resistance markedly limits its efficacy (124)

Risk factors include pregnancy, obesity, hypertension and diabetes Signs/Symptoms Drooping of eyelid or an inability to completely close the eye Drooping of the corner of the mouth Unable to raise an eyebrow or wrinkle the forehead Additional symptoms (related to facial nerve function) Dry eye with epiphora (excessive tearing) Ipsilateral loss of taste sensation Hyperacusis Differential diagnosis Central Lesion of the facial nucleus of the brain stem, UMNL Ramsy Hunt syndrome (Herpes Zoster oticus), painful rash in ear Miller Fisher variant GBS Note: Can present as a polyneuritis involving trigeminal, glossopharyngeal, 2 nd cervical or vagal nerve

Think of this acetyl group as a protective suit of armor

Should Glutathione Be Avoided During the First Trimester