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Thus, understanding the specific mechanisms of mitophagy, particularly the regulation of PINK1/Parkin, Bnip3/Nix and FUNDC1 pathways, may lead to novel therapeutic targets in AP (128)

3 There has been controversy over the classification of NAC as a licensed medicine or a supplement in the USA, and the US Food and Drug Administration (FDA) excluded NAC from the dietary supplement definition in 2020

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7.2 Unanswered questions and research priorities Several key questions remained unanswered

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