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This bulky residue prevents efficient binding of both glutathione and hydrophobic substrates through steric hindrance

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BioMed Res Int (2018) 2018:17

GSTs protect tissues from endogenous organic hydroperoxides produced during oxidative stress [35,45]

Leu5 of ghrelin also forms hydrophobic interactions with GHSR residues F286 6.58 and F290 6.62 (Fig