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PMID 17147644

J Cell Biochem (2008) 105(5):114752

Magri, G

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Among these, the expression of Cyp7a1, a BA synthesis enzyme, was insulin-dependent and was markedly decreased in Insr P1195L/ +/HFD liver

When intracellular glutathione levels are sufficient, this feedback mechanism suppresses further synthesis, preventing excessive accumulation of pathway intermediates